Update week4.md

docs/week4.md

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 📖 [What Is Your Research Question? An Introduction to the PICOT Format for Clinicians](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430448/)<br />  
 
-1. Use [chat GPT](chatgpt.com) to generate a hypothetical statistical consulting scenario. Ask the following questions:
+1. Use [chat GPT](chatgpt.com) to generate a hypothetical biostatistical consulting scenario. Ask the following questions that will assess the PICOT criteria:
      * What is the population of interest for this study?
+       * Note the difference between the target population and the actual sample.
      * Are there any exclusion and/or inclusion criteria?
+       * Note whether these criteria align with the target population.
      * Is there any issue with generalizability?
+       * Note what mechanisms are suggested for improving generalizability.
      * What is the intervention/treatment group?
      * What is the comparison/control group?
      * What is the outcome of this study?
      * Is time an important component?
 
-2. What else would you want to know about the research question? Think about general information about the study, the variables being used, and the target population.
-3. Do you have an idea of a type of analysis you could perform? What additional information do you think you might need from the client?
+2. Is there else would you want to know about the research question? Think about general information about the study, the study design, and the variables being used.
+3. Do you have an idea of a type of analysis you could perform? If not, what additional information do you think you might need from the client when making this determination?
 
 
 ### In Class